Frailty involves complex mechanisms of cumulative decline in several physiological systems and is associated with adverse events that are determined by genetic and environmental factors. It has been reported that angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphisms are associated...
This study presents a brief review of 6 articles published between 2001 and 2014 that examined the prevalence of frailty as defined by the Fried scale in community-dwelling adults representative of the national population, age 65 years and older.
Several studies have highlighted a link between vascular alterations and cognitive decline. The PARTAGE study showed that arterial stiffness as evaluated by carotid-femoral pulse wave velocity (cfPWV) was associated with a more pronounced cognitive decline over a 1-year period in very old frail institution...
The objective of this study was to establish the extent to which frailty was associated with attrition and then compare estimates of frailty prevalence and progression estimated from the observed data to those estimated after imputation.
To determine whether the number of attending general practitioners (GPs) in nursing homes and other facility characteristics are associated with inappropriate neuroleptic prescribing.
The objective of this study was to examine whether the capacity of an age-related deficit accumulation index (the so-called Frailty Index [FI] proposed by Rockwood) to predict mortality in a nursing home population.
Postprandial hypotension (PPH) occurs frequently in older individuals with disease and/or living in residential care, but its prevalence in “healthy” older individuals has not been evaluated in large cohorts. PPH is associated with substantial morbidity and increased mortality; current management is subopt...
Physical activity is critically important for successful aging, but its effect on adiposity markers at older ages is unclear as much of the evidence comes from self-reported data on physical activity. We assessed the associations of questionnaire-assessed and accelerometer-assessed physical activity with a...